RDBE-Distribution

The rings-plus-double-bonds equivalent (RDBE) measures the number of rings and double bonds in the molecule. The RDBE values calculated using the most common valences for the elements remain within a certain range for biologically relevant molecules. The RDBE values of molecules in the KEGG database are gamma distributed. As the values between -1 and 2 are not well approximated by the distribution, we use counting statistics to assign the scores in this interval.

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